Reteplase (Recombinant) Solution for injection

What is this medicine?

RETEPLASE (RE te plays) is used to dissolve blood clots that form in certain blood vessels. This medicine is used when a blood clot in a heart artery causes a heart attack.

How should I use this medicine?

This medicine is for injection into a vein. It is usually given by a health care professional in a hospital or clinic setting.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • signs and symptoms of bleeding such as bloody or black, tarry stools; red or dark-brown urine; spitting up blood or brown material that looks like coffee grounds; red spots on the skin; unusual bruising or bleeding from the eye, gums, or nose

  • signs and symptoms of a stroke such as changes in vision; confusion; trouble speaking or understanding; severe headaches; sudden numbness or weakness of the face, arm, or leg; trouble walking, dizziness, loss of balance or coordination

  • slow or fast heart rate

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • dizziness

  • fever

  • nausea, vomiting

What may interact with this medicine?

Do not take this medicine with any of the following medications:

  • aminocaproic acid

  • aprotinin

  • tranexamic acid

This medicine may also interact with the following medications:

  • antiplatelet drugs such as ticlopidine or clopidogrel

  • aspirin and aspirin-like drugs

  • medicines that treat or prevent blood clots like warfarin, heparin, enoxaparin, and dalteparin

  • NSAIDs, medicines for pain and inflammation, like ibuprofen or naproxen

What if I miss a dose?

This does not apply.

Where should I keep my medicine?

This drug is given in a hospital or clinic and will not be stored at home.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • aneurysm

  • bleeding problems or problems with blood clotting

  • diabetic retinopathy or bleeding problems of the eye

  • endocarditis (infection of the heart valves)

  • head injury, brain disease, or tumor

  • high blood pressure

  • infection

  • irregular heartbeats

  • kidney disease

  • liver disease

  • mitral stenosis

  • recent biopsy, childbirth, surgery, or trauma (injury)

  • recent history of stroke

  • stomach ulcer or bleeding ulcer-an unusual or allergic reaction to reteplase, other medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

What should I watch for while using this medicine?

You will be closely monitored to check your progress after you receive this medicine. Follow the advice of your doctor or health care professional exactly. You may need bed rest to minimize the risk of bleeding.

This medicine can make you bleed more easily. This effect can last for several days. Try to avoid damage to your teeth and gums when you brush or floss your teeth, and try to avoid any other injury to yourself.

Do not take aspirin, ibuprofen, or other nonprescription pain relievers during or for several days after treatment with this medicine unless otherwise told to do so by your doctor or health care professional.



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