Pazopanib Oral tablet

What is this medicine?

PAZOPANIB (paz OH pa nib) is a biologic drug used to treat kidney cancer and sarcoma.

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Do not cut, crush or chew this medicine. Take this medicine on an empty stomach, at least 1 hour before or 2 hours after meals. Do not take with food. Do not take with grapefruit juice. Take your medicine at regular intervals. Do not take it more often than directed. Do not stop taking except on your doctor’s advice.

A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • abdominal pain

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • black, tarry stool

  • breathing problems

  • changes in vision

  • chest pain

  • confusion, trouble speaking or understanding

  • cough

  • fast, irregular heartbeat

  • fever or chills, sore throat

  • seizures

  • severe headaches

  • shortness or breath

  • sudden numbness or weakness of the face, arm or leg

  • trouble passing urine or change in the amount of urine

  • trouble walking, dizziness, loss of balance or coordination

  • unusual bleeding or bruising

  • unusually weak or tired

  • yellowing of the eyes or skin

Side effects that usually do not require medical attention (Report these to your doctor or health care professional if they continue or are bothersome.):

  • change in hair color

  • loose or watery stool

  • loss of appetite

  • nausea, vomiting

  • unusually weak or tired

What may interact with this medicine?

Do not take this medication with any of the following medications:

  • rifampin

This medicine may also interact with the following medications:

  • certain medicines for stomach problems like cimetidine, famotidine, omeprazole, lansoprazole

  • clarithromycin

  • dextromethorphan

  • grapefruit or grapefruit juice

  • ketoconazole

  • lapatinib

  • certain medicines for irregular heart beat like amiodarone, bepridil, dofetilide, encainide, flecainide, propafenone, quinidine

  • midazolam

  • paclitaxel

  • ritonavir

What if I miss a dose?

If you miss a dose, take it as soon as you can. If your next dose is to be taken in less than 12 hours, then do not take the missed dose. Take the next dose at your regular time. Do not take double or extra doses.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • bleeding problems

  • have had recent surgery (within 7 days) or are having surgery

  • heart disease

  • high blood pressure

  • history of stroke

  • liver disease

  • protein in your urine

  • stomach or intestine problems

  • thyroid problems

  • an unusual or allergic reaction to pazopanib, other medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

What should I watch for while using this medicine?

Visit your doctor for regular check ups. You will need to have blood work while you are taking this medicine.

Call your doctor or health care professional for advice if you get a fever, chills or sore throat, or other symptoms of a cold or flu. Do not treat yourself. This drug decreases your body’s ability to fight infections. Try to avoid being around people who are sick.

This medicine may increase your risk to bruise or bleed. Call your doctor or health care professional if you notice any unusual bleeding.

Do not become pregnant while taking this medicine or for 2 weeks after stopping it. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information. Do not breast-feed an infant while taking this medicine.

This medicine may interfere with the ability to have a child. You should talk with your doctor or health care professional if you are concerned about your fertility.

If you are going to have surgery or any other procedures, tell your doctor you are taking this medicine.



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