Dolasetron Mesylate Monohydrate Solution for injection

What is this medicine?

DOLASETRON (dol A se tron) is used to treat and prevent nausea and vomiting after surgery.

How should I use this medicine?

This medicine is for infusion into a vein. It is given by a health-care professional in a hospital or clinic setting.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed. While this medicine may be prescribed for children as young as 2 years for selected conditions, precautions do apply.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • breathing problems

  • chest tightness

  • confusion

  • dizziness

  • fast or irregular heartbeat

  • feeling faint or lightheaded, falls

  • fever and chills

  • loss of balance or coordination

  • seizures

  • sweating

  • swelling of the feet or hands

  • tremors

  • unusually weak or tired

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • constipation or diarrhea

  • headache

What may interact with this medicine?

Do not take this medicine with any of the following medications:

  • certain medicines for fungal infections like fluconazole, itraconazole, ketoconazole, posaconazole, voriconazole

  • cisapride

  • dofetilide

  • dronedarone

  • pimozide

  • thioridazine

  • ziprasidone

This medicine may also interact with the following medications:

  • antiviral medicines for HIV or AIDS

  • beta-blockers like atenolol, metoprolol, propranolol

  • calcium channel blockers like diltiazem, verapamil

  • certain medicines for depression, anxiety, or psychotic disturbances

  • cimetidine

  • daunorubicin

  • digoxin

  • diuretics

  • doxorubicin

  • epirubicin

  • fentanyl

  • flecainide

  • linezolid

  • MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate

  • methylene blue (injected into a vein)

  • other medicines that prolong the QT interval (cause an abnormal heart rhythm)

  • quinidine

  • rifampin

  • tramadol

What if I miss a dose?

This does not apply.

Where should I keep my medicine?

This drug is given in a hospital or clinic and will not be stored at home.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • heart disease

  • history of irregular heartbeat

  • kidney disease

  • low levels of magnesium or potassium in the blood

  • an unusual or allergic reaction to dolasetron, granisetron, ondansetron, other medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

What should I watch for while using this medicine?

Your condition will be monitored carefully while you are receiving this medicine.



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